The KNOTTIN database

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236 references found

Abdeen, A., Virgos, A., Olivella, E., Villanueva, J., Aviles, X., Gabarra, R. & Prat, S. (2005) Multiple insect resistance in transgenic tomato plants over-expressing two families of plant proteinase inhibitors. Plant Mol Biol, 57(2):189-202

Altschul, S.F., Gish, W., Miller, W., Myers, E.W. & Lipman, D.J. (1990) Basic local alignment search tool. J Mol Biol, 215(3):403-10.

Arolas, J.L., Aviles, F.X., Chang, J.Y. & Ventura, S. (2006) Folding of small disulfide-rich proteins: clarifying the puzzle. Trends Biochem Sci, 31(5):292-301

Avrutina, O., Schmoldt, H.U., Gabrijelcic-Geiger, D., Wentzel, A., Frauendorf, H., Sommerhoff, C.P., Diederichsen, U. & Kolmar, H. (2008) Head-to-tail cyclized cystine-knot peptides by a combined recombinant and chemical route of synthesis. Chembiochem, 9(1):33-7

Ay, J., Hilpert, K., Krauss, N., Schneider-Mergener, J. & Hohne, W. (2003) Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution. Acta Crystallogr D Biol Crystallogr, 59(Pt 2):247-54.

Baggio, R., Burgstaller, P., Hale, S.P., Putney, A.R., Lane, M., Lipovsek, D., Wright, M.C., Roberts, R.W., Liu, R., Szostak, J.W. & Wagner, R.W. (2002) Identification of epitope-like consensus motifs using mRNA display. J Mol Recognit, 15(3):126-34.

Barbault, F., Landon, C., Guenneugues, M., Meyer, J.P., Schott, V., Dimarcq, J.L. & Vovelle, F. (2003) Solution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus. Biochemistry, 42(49):14434-42

Barbeta, B.L., Marshall, A.T., Gillon, A.D., Craik, D.J. & Anderson, M.A. (2008) Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae. Proc Natl Acad Sci U S A, 105(4):1221-5

Barry, D.G., Daly, N.L., Clark, R.J., Sando, L. & Craik, D.J. (2003) Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry, 42(22):6688-95.

Basse, C.W. (2005) Dissecting defense-related and developmental transcriptional responses of maize during Ustilago maydis infection and subsequent tumor formation. Plant Physiol, 138(3):1774-84

Becker, S. & Terlau, H. (2008) Toxins from cone snails: properties, applications and biotechnological production. Appl Microbiol Biotechnol, 79(1):1-9

Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N., Weissig, H., Shindyalov, I.N. & Bourne, P.E. (2000) The Protein Data Bank. Nucleic Acids Res, 28(1):235-42.

Bernard, C., Corzo, G., Mosbah, A., Nakajima, T. & Darbon, H. (2001) Solution structure of Ptu1, a toxin from the assassin bug Peirates turpis that blocks the voltage-sensitive calcium channel N-type. Biochemistry, 40(43):12795-800.

Binz, H.K., Amstutz, P. & Pluckthun, A. (2005) Engineering novel binding proteins from nonimmunoglobulin domains. Nat Biotechnol, 23(10):1257-68

Blanco-Aparicio, C., Molina, M.A., Fernandez-Salas, E., Frazier, M.L., Mas, J.M., Querol, E., Aviles, F.X. & de Llorens, R. (1998) Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. J Biol Chem, 273(20):12370-7.

Bode, W., Greyling, H.J., Huber, R., Otlewski, J. & Wilusz, T. (1989) The refined 2.0 A X-ray crystal structure of the complex formed between bovine beta-trypsin and CMTI-I, a trypsin inhibitor from squash seeds (Cucurbita maxima). Topological similarity of the squash seed inhibitors with the carboxypeptidase A inhibitor from potatoes. FEBS Lett, 242(2):285-92.

Boeckmann, B., Bairoch, A., Apweiler, R., Blatter, M.C., Estreicher, A., Gasteiger, E., Martin, M.J., Michoud, K., O'Donovan, C., Phan, I., Pilbout, S. & Schneider, M. (2003) The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res, 31(1):365-70.

Bohlen, C.J., Priel, A., Zhou, S., King, D., Siemens, J. & Julius, D. (2010) A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell, 141(5):834-45

Bolin, K.A., Anderson, D.J., Trulson, J.A., Thompson, D.A., Wilken, J., Kent, S.B., Gantz, I. & Millhauser, G.L. (1999) NMR structure of a minimized human agouti related protein prepared by total chemical synthesis. FEBS Lett, 451(2):125-31.

Boulegue, C., Musiol, H.J., Prasad, V. & Moroder, L. (2006) Synthsesis of cystein-rich peptides. Chemistry Today, 24(4):24-36

Bronsoms, S., Villanueva, J., Canals, F., Querol, E. & Aviles, F.X. (2003) Analysis of the effect of potato carboxypeptidase inhibitor pro-sequence on the folding of the mature protein. Eur J Biochem, 270(17):3641-50.

Brown, N.P., Leroy, C. & Sander, C. (1998) MView: a web-compatible database search or multiple alignment viewer. Bioinformatics, 14(4):380-1.

Buczek, O., Green, B.R. & Bulaj, G. (2007) Albumin is a redox-active crowding agent that promotes oxidative folding of cysteine-rich peptides. Biopolymers, 88(1):8-19

Buczek, O., Olivera, B.M. & Bulaj, G. (2004) Propeptide does not act as an intramolecular chaperone but facilitates protein disulfide isomerase-assisted folding of a conotoxin precursor. Biochemistry, 43(4):1093-101.

Buczek, P., Buczek, O. & Bulaj, G. (2005) Total chemical synthesis and oxidative folding of delta-conotoxin PVIA containing an N-terminal propeptide. Biopolymers, 80(1):50-7

Bulaj, G. & Olivera, B.M. (2008) Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptides. Antioxid Redox Signal, 10(1):141-55

Camarero, J.A. & Mitchell, A.R. (2005) Synthesis of proteins by native chemical ligation using Fmoc-based chemistry. Protein Pept Lett, 12(8):723-8

Camarero, J.A., Kimura, R.H., Woo, Y.H., Shekhtman, A. & Cantor, J. (2007) Biosynthesis of a fully functional cyclotide inside living bacterial cells. Chembiochem, 8(12):1363-6

Cammue, B.P., De Bolle, M.F., Terras, F.R., Proost, P., Van Damme, J., Rees, S.B., Vanderleyden, J. & Broekaert, W.F. (1992) Isolation and characterization of a novel class of plant antimicrobial peptides form Mirabilis jalapa L. seeds. J Biol Chem, 267(4):2228-33.

Carugo, O., Lu, S., Luo, J., Gu, X., Liang, S., Strobl, S. & Pongor, S. (2001) Structural analysis of free and enzyme-bound amaranth alpha-amylase inhibitor: classification within the knottin fold superfamily and analysis of its functional flexibility. Protein Eng, 14(9):639-46.

Cascales, L., Henriques, S.T., Kerr, M.C., Huang, Y.H., Sweet, M.J., Daly, N.L. & Craik, D.J. (2011) Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. J Biol Chem, 286(42):36932-43

Cemazar, M., Daly, N.L., Haggblad, S., Lo, K.P., Yulyaningsih, E. & Craik, D.J. (2006) Knots in rings. The circular knotted protein Momordica cochinchinensis trypsin inhibitor-II folds via a stable two-disulfide intermediate. J Biol Chem, 281(12):8224-32

Cemazar, M., Gruber, C.W. & Craik, D.J. (2008) Oxidative folding of cyclic cystine knot proteins. Antioxid Redox Signal, 10(1):103-11

Cemazar, M., Joshi, A., Daly, N.L., Mark, A.E. & Craik, D.J. (2008) The structure of a two-disulfide intermediate assists in elucidating the oxidative folding pathway of a cyclic cystine knot protein. Structure, 16(6):842-51

Cemazar, M., Zahariev, S., Lopez, J.J., Carugo, O., Jones, J.A., Hore, P.J. & Pongor, S. (2003) Oxidative folding intermediates with nonnative disulfide bridges between adjacent cysteine residues. Proc Natl Acad Sci U S A, 100(10):5754-9

Cemazar, M., Zahariev, S., Pongor, S. & Hore, P.J. (2004) Oxidative folding of Amaranthus alpha-amylase inhibitor: disulfide bond formation and conformational folding. J Biol Chem, 279(16):16697-705

Chai, B.X., Neubig, R.R., Millhauser, G.L., Thompson, D.A., Jackson, P.J., Barsh, G.S., Dickinson, C.J., Li, J.Y., Lai, Y.M. & Gantz, I. (2003) Inverse agonist activity of agouti and agouti-related protein. Peptides, 24(4):603-9.

Chakraborty, S., Bhattacharya, S., Ghosh, S., Bera, A.K., Haldar, U., Pal, A.K., Mukhopadhyay, B.P. & Banerjee, A. (2000) Structural and interactional homology of clinically potential trypsin inhibitors: molecular modelling of cucurbitaceae family peptides using the X-ray structure of MCTI-II. Protein Eng, 13(8):551-5.

Chang, J.Y., Canals, F., Schindler, P., Querol, E. & Aviles, F.X. (1994) The disulfide folding pathway of potato carboxypeptidase inhibitor. J Biol Chem, 269(35):22087-94.

Chang, J.Y., Li, L. & Bulychev, A. (2000) The underlying mechanism for the diversity of disulfide folding pathways. J Biol Chem, 275(12):8287-9.

Chang, J.Y., Li, L., Canals, F. & Aviles, F.X. (2000) The unfolding pathway and conformational stability of potato carboxypeptidase inhibitor. J Biol Chem, 275(19):14205-11.

Chen, B., Colgrave, M.L., Wang, C. & Craik, D.J. (2006) Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. J Nat Prod, 69(1):23-8

Chen, X.M., Qian, Y.W., Chi, C.W., Gan, K.D., Zhang, M.F. & Chen, C.Q. (1992) Chemical synthesis, molecular cloning, and expression of the gene coding for the Trichosanthes trypsin inhibitor--a squash family inhibitor. J Biochem (Tokyo), 112(1):45-51

Chiche, L., Gaboriaud, C., Heitz, A., Mornon, J.P., Castro, B. & Kollman, P.A. (1989) Use of restrained molecular dynamics in water to determine three-dimensional protein structure: prediction of the three-dimensional structure of Ecballium elaterium trypsin inhibitor II. Proteins, 6(4):405-17.

Chiche, L., Heitz, A., Gelly, J.C., Gracy, J., Chau, P.T., Ha, P.T., Hernandez, J.F. & Le-Nguyen, D. (2004) Squash inhibitors: from structural motifs to macrocyclic knottins. Curr Protein Pept Sci, 5(5):341-349

Chiche, L., Heitz, A., Padilla, A., Le-Nguyen, D. & Castro, B. (1993) Solution conformation of a synthetic bis-headed inhibitor of trypsin and carboxypeptidase A: new structural alignment between the squash inhibitors and the potato carboxypeptidase inhibitor. Protein Eng, 6(7):675-82.

Chino, N., Kubo, S., Hideki, N., Nishiuchi, Y., Nakazato, M. & Kimura, T. (2006) Chemical Synthesis of Human -Defensin (hBD)-1, -2, -3 and -4: Optimization of the Oxidative Folding Reaction. Int J Pept Res Ther, 12(3):203-209

Choi, S.J., Parent, R., Guillaume, C., Deregnaucourt, C., Delarbre, C., Ojcius, D.M., Montagne, J.J., Celerier, M.L., Phelipot, A., Amiche, M., Molgo, J., Camadro, J.M. & Guette, C. (2004) Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei. FEBS Lett, 572(1-3):109-17

Christmann, A., Walter, K., Wentzel, A., Kratzner, R. & Kolmar, H. (1999) The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides. Protein Eng, 12(9):797-806.

Clark, R.J., Daly, N.L. & Craik, D.J. (2006) Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochem J, 394(Pt 1):85-93

Clark, R.J., Jensen, J., Nevin, S.T., Callaghan, B.P., Adams, D.J. & Craik, D.J. (2010) The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew Chem Int Ed Engl, 49(37):6545-8

Colgrave, M.L., Kotze, A.C., Ireland, D.C., Wang, C.K. & Craik, D.J. (2008) The anthelmintic activity of the cyclotides: natural variants with enhanced activity. Chembiochem, 9(12):1939-45

Combelles, C., Gracy, J., Heitz, A., Craik, D.J. & Chiche, L. (2008) Structure and folding of disulfide-rich miniproteins: Insights from molecular dynamics simulations and MM-PBSA free energy calculations. Proteins, 

Craik, D., Daly, N.L. & Nielsen, K.J. (2000) Preparation of cyclized conotoxin peptides. Journal, (Issue)

Craik, D.J. (2001) Plant cyclotides: circular, knotted peptide toxins. Toxicon, 39(12):1809-13.

Craik, D.J. (2010) The folding of disulfide-rich proteins. Antioxid Redox Signal, 14(1):61-4

Craik, D.J., Cemazar, M. & Daly, N.L. (2006) The cyclotides and related macrocyclic peptides as scaffolds in drug design. Curr Opin Drug Discov Devel, 9(2):251-60

Craik, D.J., Daly, N.L. & Waine, C. (2001) The cystine knot motif in toxins and implications for drug design. Toxicon, 39(1):43-60.

Craik, D.J., Daly, N.L., Bond, T. & Waine, C. (1999) Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. J Mol Biol, 294(5):1327-36.

Craik, D.J., Simonsen, S. & Daly, N.L. (2002) The cyclotides: novel macrocyclic peptides as scaffolds in drug design. Curr Opin Drug Discov Devel, 5(2):251-60.

Crich, D. & Banerjee, A. (2007) Native chemical ligation at phenylalanine. J Am Chem Soc, 129(33):10064-5

Cui, T., Gao, Y., Liew, O.W., Puah, C.M. & Gutte, B. (2007) Efficient preparation of an acyclic permutant of kalata B1 from a recombinant fusion protein with thioredoxin. J Biotechnol, 130(4):378-84

Daly, N.L. & Craik, D.J. (2000) Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1. J Biol Chem, 275(25):19068-75.

Daly, N.L., Clark, R.J. & Craik, D.J. (2003) Disulfide Folding Pathways of Cystine Knot Proteins. Tying the knot within the circular backbone of the cyclotides. J Biol Chem, 278(8):6314-22.

Daly, N.L., Clark, R.J., Plan, M.R. & Craik, D.J. (2006) Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochem J, 393(Pt 3):619-26

Daly, N.L., Love, S., Alewood, P.F. & Craik, D.J. (1999) Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1. Biochemistry, 38(32):10606-14.

Davis, J.H., Bradley, E.K., Miljanich, G.P., Nadasdi, L., Ramachandran, J. & Basus, V.J. (1993) Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis. Biochemistry, 32(29):7396-405.

Dawson, P.E., Muir, T.W., Clark-Lewis, I. & Kent, S.B. (1994) Synthesis of proteins by native chemical ligation. Science, 266(5186):776-9

DeLa Cruz, R., Whitby, F.G., Buczek, O. & Bulaj, G. (2003) Detergent-assisted oxidative folding of delta-conotoxins. J Pept Res, 61(4):202-12.

Dupas, S., Turnbull, M.W. & Webb, B.A. (2003) Diversifying selection in a parasitoid's symbiotic virus among genes involved in inhibiting host immunity. Immunogenetics, 55(6):351-61

Durbin, R., Eddy, S., Krogh, A. & Mitchison, G. (1998) Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids. , :Pages

Durek, T., Zhang, J., He, C. & Kent, S.B. (2007) Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein. Org Lett, 9(26):5497-500

Einerwold, J., Jaseja, M., Hapner, K., Webb, B. & Copie, V. (2001) Solution structure of the carboxyl-terminal cysteine-rich domain of the VHv1.1 polydnaviral gene product: comparison with other cystine knot structural folds. Biochemistry, 40(48):14404-12

Escoubas, P., Bernard, C., Lambeau, G., Lazdunski, M. & Darbon, H. (2003) Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci, 12(7):1332-43

Esteve, E., Mabrouk, K., Dupuis, A., Smida-Rezgui, S., Altafaj, X., Grunwald, D., Platel, J.C., Andreotti, N., Marty, I., Sabatier, J.M., Ronjat, M. & De Waard, M. (2005) Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane. J Biol Chem, 280(13):12833-9

Favel, A., Le-Nguyen, D., Coletti-Previero, M.A. & Castro, B. (1989) Active site chemical mutagenesis of Ecballium elaterium trypsin inhibitor II: new microproteins inhibiting elastase and chymotrypsin. Biochem Biophys Res Commun, 162(1):79-82.

Favel, A., Mattras, H., Coletti-Previero, M.A., Zwilling, R., Robinson, E.A. & Castro, B. (1989) Protease inhibitors from Ecballium elaterium seeds. Int J Pept Protein Res, 33(3):202-208

Felizmenio-Quimio, M.E., Daly, N.L. & Craik, D.J. (2001) Circular proteins in plants: solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis. J Biol Chem, 276(25):22875-82.

Flinn, J.P., Pallaghy, P.K., Lew, M.J., Murphy, R., Angus, J.A. & Norton, R.S. (1999) Role of disulfide bridges in the folding, structure and biological activity of omega-conotoxin GVIA. Biochim Biophys Acta, 1434(1):177-90.

Franco, O.L., Rigden, D.J., Melo, F.R. & Grossi-De-Sa, M.F. (2002) Plant alpha-amylase inhibitors and their interaction with insect alpha-amylases. Eur J Biochem, 269(2):397-412.

Fujitani, N., Kawabata, S., Osaki, T., Kumaki, Y., Demura, M., Nitta, K. & Kawano, K. (2002) Structure of the antimicrobial peptide tachystatin A. J Biol Chem, 277(26):23651-7.

Fuller, E., Green, B.R., Catlin, P., Buczek, O., Nielsen, J.S., Olivera, B.M. & Bulaj, G. (2005) Oxidative folding of conotoxins sharing an identical disulfide bridging framework. Febs J, 272(7):1727-38

Gantz, I. & Fong, T.M. (2003) The melanocortin system. Am J Physiol Endocrinol Metab, 284(3):E468-74

Gao, G.H., Liu, W., Dai, J.X., Wang, J.F., Hu, Z., Zhang, Y. & Wang, D.C. (2001) Molecular scaffold of a new pokeweed antifungal peptide deduced by 1H nuclear magnetic resonance. Int J Biol Macromol, 29(4-5):251-8.

Gao, G.H., Liu, W., Dai, J.X., Wang, J.F., Hu, Z., Zhang, Y. & Wang, D.C. (2001) Solution structure of PAFP-S: a new knottin-type antifungal peptide from the seeds of Phytolacca americana. Biochemistry, 40(37):10973-8.

Garcia, M.L. (2004) Ion channels: gate expectations. Nature, 430(6996):153-5

Garcia-Olmedo, F., Molina, A., Alamillo, J.M. & Rodriguez-Palenzuela, P. (1998) Plant defense peptides. Biopolymers, 47(6):479-91.

Gelly, J.C., Gracy, J., Kaas, Q., Le-Nguyen, D., Heitz, A. & Chiche, L. (2004) The KNOTTIN website and database: a new information system dedicated to the knottin scaffold. Nucleic Acids Res, 32(Database issue):D156-9

Goransson, U. & Craik, D.J. (2003) Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. J Biol Chem, 278(48):48188-96

Goransson, U., Luijendijk, T., Johansson, S., Bohlin, L. & Claeson, P. (1999) Seven novel macrocyclic polypeptides from Viola arvensis. J Nat Prod, 62(2):283-6.

Gowd, K.H., Yarotskyy, V., Elmslie, K.S., Skalicky, J.J., Olivera, B.M. & Bulaj, G. (2010) Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry, 49(12):2741-52

Gran, L., Sandberg, F. & Sletten, K. (2000) Oldenlandia affinis (R&S) DC. A plant containing uteroactive peptides used in African traditional medicine. J Ethnopharmacol, 70(3):197-203.

Green, B.R., Catlin, P., Zhang, M.M., Fiedler, B., Bayudan, W., Morrison, A., Norton, R.S., Smith, B.J., Yoshikami, D., Olivera, B.M. & Bulaj, G. (2007) Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity. Chem Biol, 14(4):399-407

Greenwood, K.P., Daly, N.L., Brown, D.L., Stow, J.L. & Craik, D.J. (2007) The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. Int J Biochem Cell Biol, 39(12):2252-64

Grzesiak, A., Buczek, O., Petry, I., Szewczuk, Z. & Otlewski, J. (2000) Inhibition of serine proteinases from human blood clotting system by squash inhibitor mutants. Biochim Biophys Acta, 1478(2):318-24.

Gunasekera, S., Daly, N.L., Clark, R.J. & Craik, D.J. (2009) Dissecting the oxidative folding of circular cystine knot miniproteins. Antioxid Redox Signal, 11(5):971-80

Gurrola, G.B., Capes, E.M., Zamudio, F.Z., Possani, L.D. & Valdivia, H.H. (2010) Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel), 3(4):1093-1107

Habib, H. & Fazili, K. (2007) Plant protease inhibitors: a defense strategy in plants. Biotechnology and Molecular Biology Review, 2(3):68-85

Hallock, Y.F., Sowder, R.C., 2nd, Pannell, L.K., Hughes, C.B., Johnson, D.G., Gulakowski, R., Cardellina, J.H., 2nd & Boyd, M.R. (2000) Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa. J Org Chem, 65(1):124-8.

Hartig, G.R., Tran, T.T. & Smythe, M.L. (2005) Intramolecular disulphide bond arrangements in nonhomologous proteins. Protein Sci, 14(2):474-82

Heitz, A., Chiche, L., Le-Nguyen, D. & Castro, B. (1995) Folding of the squash trypsin inhibitor EETI II. Evidence of native and non-native local structural preferences in a linear analogue. Eur J Biochem, 233(3):837-46.

Heitz, A., Chiche, L., Le-Nguyen, D. & Castro, B. (1989) 1H 2D NMR and distance geometry study of the folding of Ecballium elaterium trypsin inhibitor, a member of the squash inhibitors family. Biochemistry, 28(6):2392-8.

Heitz, A., Hernandez, J.F., Gagnon, J., Hong, T.T., Pham, T.T., Nguyen, T.M., Le-Nguyen, D. & Chiche, L. (2001) Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins. Biochemistry, 40(27):7973-83.

Heitz, A., Le-Nguyen, D. & Chiche, L. (1999) Min-21 and min-23, the smallest peptides that fold like a cystine-stabilized beta-sheet motif: design, solution structure, and thermal stability. Biochemistry, 38(32):10615-25.

Heitz, A., Le-Nguyen, D., Castro, B. & Chiche, L. (1997) Conformational study of a native monodisulfide bridge analogue of EETI-II. Lett. in Pep. Sci., 4:245-249

Heitz, A., Le-Nguyen, D., Dumas, C. & Chiche, L. (2000) Engineering Potential Inhibitors of the Interaction Between the HIV-1 NEF protein and Kinase SH3 domains. Peptides 2000, :415-416

Hernandez, J.F., Gagnon, J., Chiche, L., Nguyen, T.M., Andrieu, J.P., Heitz, A., Trinh Hong, T., Pham, T.T. & Le-Nguyen, D. (2000) Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure. Biochemistry, 39(19):5722-30.

Hilpert, K., Schneider-Mergener, J. & Ay, J. (2002) Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor. Acta Crystallogr D Biol Crystallogr, 58(Pt 4):672-4.

Horita, S., Matsushita, N., Kawachi, T., Ayabe, R., Miyashita, M., Miyakawa, T., Nakagawa, Y., Nagata, K., Miyagawa, H. & Tanokura, M. (2011) Solution structure of a short-chain insecticidal toxin LaIT1 from the venom of scorpion Liocheles australasiae. Biochem Biophys Res Commun, 411(4):738-44

Hosse, R.J., Rothe, A. & Power, B.E. (2006) A new generation of protein display scaffolds for molecular recognition. Protein Sci, 15(1):14-27

Ilnytska, O. & Argyropoulos, G. (2008) The Role of the Agouti-Related Protein in Energy Balance Regulation. Cell Mol Life Sci, 

Ireland, D.C., Colgrave, M.L., Nguyencong, P., Daly, N.L. & Craik, D.J. (2006) Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins. J Mol Biol, 357(5):1522-35

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