Conotoxins and spider toxins that block voltage-sensitive calcium chanels are potent analgesics
Neurotoxin Tx3-6 from brazilian armed spider
displayed higher efficacy and long-lasting analgesia in a thermal model of pain,
when compared with omega-conotoxin MVIIA. Tx3-6 was also more effective to reverse previously
installed persistent chemical and neuropathic pain. It is suggested that Tx3-6 might be useful
in the control of persistent pathological pain
[Souza et al., 2008].
The tarantula spider toxin GsMTx4
was shown to reduce mechanical and neuropathic pain . However, GsMTx4 did not
affect response to thermal stimuli
[Park et al., 2008].
Omega-conotoxin MVIIA (Ziconotide) is a potent
analgesic and has been approved for the treatment of severe chronic pain