The KNOTTIN database

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2011

The first knottin... that is not a knottin !

A two-disulfide toxin from the venom of scorpion Liocheles australasiae, LaIT1, has been shown to display a knottin fold [Horita et al., 2011]. Although two-disulfide knottin-like domains were predicted to be stable many years ago [Le-Nguyen et al., 1993; Heitz et al., 1999], this is however, to our knowledge, the first evidence of a wild two-disullfide knottin-like miniprotein without additional domains or disulfide bridges.
As there is no cystine knot in this toxin, it has not been included in the KNOTTIN database. The PDB ID for LaIT1 is 2lds.